منابع مشابه
Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers.
Exonic splicing regulatory sequences (ESRs) are cis-acting factor binding sites that regulate constitutive and alternative splicing. A computational method based on the conservation level of wobble positions and the overabundance of sequence motifs between 46,103 human and mouse orthologous exons was developed, identifying 285 putative ESRs. Alternatively spliced exons that are either short in ...
متن کاملPulling out gene silencers
eterochromatin’s repressive hold on DNA transcription can only be relinquished when activators enter the nucleus. Or so the theory goes. But now Vanessa Witte, Andreas Baur (University of Erlangen, Germany), and colleagues find that a heterochromatin component can be pulled from the nucleus by both the HIV protein Nef and activated integrins. “This is a really new concept—that chromatin-associa...
متن کاملIdentification of splicing silencers and enhancers in sense Alus: a role for pseudoacceptors in splice site repression.
Auxiliary splicing signals in introns play an important role in splice site selection, but these elements are poorly understood. We show that a subset of serine/arginine (SR)-rich proteins activate a cryptic 3' splice site in a sense Alu repeat located in intron 4 of the human LST1 gene. Utilization of this cryptic splice site is controlled by juxtaposed Alu-derived splicing silencers and enhan...
متن کاملIn Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs Appropriate Expression
The Aicda gene encodes activation-induced cytidine deaminase (AID). Aicda is strongly transcribed in activated B cells to diversify immunoglobulin genes, but expressed at low levels in various other cells in response to physiological or pathological stimuli. AID's mutagenic nature has been shown to be involved in tumor development. Here, we used a transgenic strategy with bacterial artificial c...
متن کاملThe Mobile-Phone Silencers Controversy
Simply put, the term “mobile phone silencer” is a generic one that describes a class of devices that disrupt mobile phone service. Their purpose is to create a “silent zone,” in which normal cell coverage is interfered with and in which mobile phones cannot operate. This, supposedly, enforces phone etiquette in places where ring tones and phone conversations are unacceptable or forbidden. Some ...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 1985
ISSN: 1958-5381,0767-0974
DOI: 10.4267/10608/3375